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05 May 2026

Vitamys – a pionering achievement in joint arthroplasty​

Mathys was the first manufacturer of orthopaedic prostheses to launch a highly cross-linked polyethylene enriched with vitamin E (VEPE) – a so-called «blended antioxidant highly cross-linked polyethylene (AO-HXLPE)» –, trademarked as vitamys. Addition of the natural antioxidant alpha-tocopherol (vitamin E) eliminates the need for heat treatment with fusing, thus preserving the good mechanical properties of polyethylene. ​

In September 2009, after several years of intensive research and development, the first RM Pressfit cup made of vitamys was implanted – a truly ground-breaking achievement in orthopaedics. ​

Vitamys is manufactured with only a stress relieving heat treatment well below the melting point, in order to ensure the dimensional stability, as well as the good mechanical strength of the material. By the addition of the natural antioxidant vitamin E, vitamys achieves its high oxidation resistance. This ensures that the excellent mechanical and tribological properties are maintained even over long periods of use.​

The advantage of vitamys lies in the beneficial combination of four properties: ​

• High elasticity for reduced stress shielding;​
• Good mechanical strength for long-term material performance;​
• High wear resistance for reduced risk of osteolysis;​
• High oxidation stability for high ageing resistance​

Reduced stress shielding and a reduced risk of osteolysis contribute significantly to bone preservation. Combined with a long-term material performance and with high resistance to ageing, this results in a durable prosthesis material. ​



Bibliography​

1 Kuzyk PRT, Saccone M, Sprague S et al. Cross-linked versus conventional polyethylene for total hip replacement. J Bone Joint Surg Br 2011;93(5):593-600​
2 Kurtz SM, Gawel HA, Patel JD. History and systematic review of wear and osteolysis outcomes for first-generation highly crosslinked polyethylene. Clin Orthop Relat Res 2011;469(8):2262-77​
3 Kurtz SM, Patel JD. The clinical performance of highly crosslinked UHMWPE in hip replacements. Kurtz SM. UHMWPE Biomaterials Handbook, 3rd Edition, 2016, Chapter 6:57-71​
4 Lerf R, Zurbrügg D, Delfosse D. Use of vitamin E to protect cross-linked UHMWPE from oxidation. Biomaterials 2010, 31:3643-8​
5Oral E et al, The effect of alpha-tocopherol on the oxidation and free radical decay in irradiated UHMWPE. Biomaterials 2006; 27: 5580–87​
6 Scientific Committee on Food (SCF) and Scientific Panel on Dietetic Products, Nutrition and Allergies (NDA) of EFSA, Tolerable Upper Intake Levels for Vitamins and Minerals, European Food Safety Authority 2006, ISBN: 92-9199-014-0 ​
7 Huiskes R, Weinans H, van Rietbergen B: The relationship between stress-shielding and bone resorption around total hip stems and the effects of flexible materials. Clin Orthop 1992,274:124–34​
8 Wirtz DC1, Schiffers N, Pandorf T, Radermacher K, Weichert D, Forst R. Critical evaluation of known bone material properties to realize anisotropic FE-simulation of the proximal femur. J Biomech 2000 Oct;33(10):1325-30​
9 Oral E, Wannomae KK, Hawkins NE, et al. a-Tocopherol doped irradiated UHMWPE for high fatigue resistance and low wear. Biomaterials 2004;25:551​
10 Oral E, Malhi A, Muratoglu O. Mechanisms of decrease in fatigue crack propagation resistance in irradiated and melted UHMWPE. Biomaterials 2006;27:917–25 ​
11 Delfosse D, Lerf R, Adlhart C. What happens to the Vitamin E in a Vitamin-Stabilised HXLPE? EFORT. 2014:197-205​
12 Knee simulator test: 10 Mio. cycles, artificial aged tibial inserts. Data on file at Mathys Ltd Bettlach ​
13 Knee simulator test: 5 Mio. cycles, artificial aged tibial inserts. Data on file at Mathys Ltd Bettlach ​
14 Alexander JJ, Bell SN, Coghlan J, Lerf R, Dallmann F. The effect of vitamin E–enhanced cross-linked polyethylene on wear in shoulder arthroplasty-a wear simulator study. J Shoulder Elbow Surg 2019;28(9):1771-8 ​
15 Dallmann F., Egger M., Joudet T. Mathys Affinis Inverse. Frankle M, Marbery S. Pupello D (Ed.), Reverse Shoulder Arthroplasty, Biomechanics, Clinical Techniques, and Current Technologies 2015 ​
16 Rochcongar G, Remazeilles M, Bourroux E, Dunet J, Chapus V, Feron M, Praz C, Buia G, Hulet C. Reduced wear in vitamin E-infused highly cross-linked polyethylene cups: 5-year results of a randomized controlled trial. Acta Orthop. 2021 Apr;92(2):151-155

Vitamys – a pionering achievement in joint arthroplasty​